Subordinate clauses

Write the correct expression among the four possibilities for each sentence.
Some sexually transmitted diseases such as syphilis and gonorrhoea are quite rare, genital herpes and HPV are still common. (despite / in spite of / whereas / therefore)
become a doctor, the hardest part is getting through the first year exam. (In order to / For / So that / When)
the patient is weak, he must undergo surgery immediately.
(However / Although / No matter how / Despite)
The experiment is dangerous the instructions are carefully followed. (however / such that / whether / unless)